When brilliant surgeon Yael Danon is selected to perform a routine operation on the Israeli prime minister it puts her and her whole family in danger. The night before the operation they are taken hostage in their house by masked men and Yael is given an ultimatum – she must kill the prime minister during his operation or her family will die.

After Dr. Ellen Sanders, a prominent Washington D.C. surgeon, is handpicked to operate on the President of the United States, rogue FBI agent Duncan Carlisle and armed intruders suddenly take her and her family hostage.